Metaraminol 10mg/ml Solution for Injection or Infusion

• Keep this leaflet. You may need to read it again.
• A nurse or doctor will give you the injection.
• If you have any further questions, ask your doctor, nurse or pharmacist.
• If you get any side effects, talk to your doctor, nurse or pharmacist.

This includes any possible side effects not listed in this leaflet. See section 4.

1. What Metaraminol is and what it is used for
2. What you need to know before you use Metaraminol
3. How to use Metaraminol
4. Possible side effects
5. How to store Metaraminol
6. Contents of the pack and other information

• if you are allergic to metaraminol tartrate or any of the other ingredients of this medicine (listed in section 6)
• with cyclopropane or halothane (anaesthetics) unless your doctor sees a clinical need to do so.

Talk to your doctor, nurse or pharmacist before using metaraminol if you have:

• Liver disease
• Heart disease
• High blood pressure
• Thyroid disease
• Diabetes mellitus
• A history of malaria.

This medicine is not recommended for use in children below the age of 12 years.

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. It is especially important if you are taking:

• Digitalis medicines (such as digoxin) which may cause an irregular heartbeat
• Monoamine oxidase inhibitors which may increase the action of metaraminol.

The effects of this medicine on the unborn baby is unknown. It is not known whether this medicine is present in breast milk. You will only be given this medicine if your doctor sees the clinical need to do so in an emergency situation.

Sodium metabisulfite - a preservative which may rarely cause severe hypersensitivity reactions and bronchospasm. It may also cause skin reactions if spilt on the skin.

Sodium - contains less than 1mmol sodium (23mg) per 10mg/ml ampoule, that is to say essentially 'sodium - free'.

In the case of an emergency, this medicine is given by direct injection into a vein, which may be followed by an infusion into a vein. The dose will be adjusted by your doctor.

The usual dose is between 0.5 - 5mg injected into the vein, followed by an infusion of 15 - 100mg in 500ml Sodium Chloride Injection or Glucose 5% Injection.

Metaraminol 10mg/ml Solution for Injection or Infusion may be used undiluted or diluted.

It is unlikely that you will receive too much because this medicine will be given to you in hospital. You will be carefully monitored by your doctor for symptoms or severely high blood pressure (see symptoms in Section 4 Possible Side Effects).

• Sudden itchy rash (hives), swelling of the hands, feet, ankles, face, lips, mouth or throat (which may cause difficulty in swallowing or breathing), feeling that you are going to faint (symptoms of a severe hypersensitivity reaction)
• Pain and/or swelling at the injection site.

• Headaches
• High blood pressure (hypertension)
• Slow, or irregular heartbeat
• Shortness of breath
• Feeling sick
• Chest pain
• Abscesses.

• Cold extremities
• Pain in the extremities.

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects, you can help provide more information on the safety of this medicine.

The active substance is metaraminol tartrate (1.9 %w/v), which is equivalent to 1.0 %w/v (10mg/ml) metaraminol.

The other ingredients are: sodium chloride, sodium metabisulfite (E223) and water for injections.

May contain traces of sodium hydroxide or hydrochloric acid (for pH adjustment).

This medicine is a clear, colourless solution free of particles.

It is available in a 1 ml clear glass ampoules with a purple coloured spot and one-point-cut score, packed into cartons containing 10 ampoules.

Other formats

To listen to or request a copy of this leaflet in Braille, large print or audio please call, free of charge: 0800 198 5000 (UK only). Please be ready to give the following information:

Product name Reference number

Metaraminol 10mg/ml Solution for Injection or Infusion PL 29831/0740

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