Tranylcypromine 10 mg Tablets

Keep this leaflet. You may need to read it again.

If you have any further questions, ask your doctor or pharmacist.

This medicine has been prescribed for you only. Do not pass it on to others.

It may harm them, even if their signs of illness are the same as yours.

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.

Tranylcypromine 10mg Tablets will be referred to as Tranylcypromine Tablets throughout this leaflet.

1. What Tranylcypromine Tablets are and what they are used for
2. What you need to know before you take Tranylcypromine Tablets
3. How to take Tranylcypromine Tablets
4. Possible side effects
5. How to store Tranylcypromine Tablets
6. Contents of the pack and other information

• you are allergic to tranylcypromine or any of the other ingredients of this medicine (listed in section 6)
• you are taking other MAOIs or have taken other MAOIs within the last two weeks
• you have taken clomipramine or imipramine within the last three weeks or are planning to take them within the next three weeks
• you suffer from porphyria (which is an inherited disease affecting the nervous system and skin)
• you have severe heart disease or any disease of the blood vessels of the brain
• you have pheochromocytoma which is a tumour of the adrenal glands (glands near the kidneys) causing high blood pressure
• you have been diagnosed with an overactive thyroid gland (a gland in the neck)
• you have known liver damage or a disorder affecting the blood cells (your doctor will know)
• you are taking any of the medicines listed under ‘Do not take’ in the “Other Medicines and Tranylcypromine Tablets” section of this leaflet.
• please tell your doctor if any of the above apply to you, and do not take Tranylcypromine Tablets.

Talk to your doctor or pharmacist before taking this medicine if you:

• are elderly
• have a mild heart problem which restricts your activity
• suffer from seizures/fits (epilepsy)
• are due to have surgery in the next few weeks
• have a history of dependence on drugs or alcohol.

Even though some of the above may be obvious, it is important that your doctor is aware if any of them apply to you.

Thoughts of suicide and worsening of your depression or anxiety disorder:

If you are depressed and/or have anxiety disorders, you can sometimes have thoughts of harming or killing yourself (see section 4 ‘Possible side effects’). These may be increased when first starting antidepressants, since these medicines all take time to work, usually about two weeks but sometimes longer.

You may be more likely to think like this if you:

• have previously had thoughts about killing or harming yourself.
• are a young adult. Information from clinical trials has shown an increased risk of suicidal behaviour in adults aged less than 25 years with psychiatric conditions who were treated with an antidepressant.

If you have thoughts of harming or killing yourself, at any time, contact your doctor or go to a hospital straight away. You may find it helpful to tell a relative or close friend that you are depressed or have an anxiety disorder, and ask them to read this leaflet. You might ask them to tell you if they think your depression or anxiety is getting worse, or if they are worried about changes in your behavior.

Tranylcypromine Tablets is not recommended for children under 18 years old (see section 3 ‘Use in children and adolescents’).

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.

DO NOT take Tranylcypromine Tablets with the following medicines:

• medicines called sympathomimetic agents - these include ephedrine, pseudoephedrine, adrenaline and noradrenaline (these may be found in medicines used to treat heart problems and asthma as well as some decongestants and cough/cold remedies)
• bupropion, a medicine to help you stop smoking
• medicines to control appetite, e.g. amphetamine and fenfluramine
• medicines that treat Parkinson’s disease, e.g. levodopa
• dopamine, a medicine used to treat certain heart conditions
• the pain killers pethidine and nefopam
• general anaesthetics such as propofol, which are used in surgery
• other medicines used to treat depression (e.g. amitriptyline, imipramine, tryptophan)
• buspirone, used to treat anxiety
• metrizamide, used as a nonionic radiopaque contrast agent

Tranylcypromine Tablets must be taken with caution if you are taking the following medicines:

• other MAOIs such as isocarboxazid
• strong pain killers e.g. codeine
• medicines to treat seizures/fits, e.g. carbamazepine
• barbiturates used to treat severe sleeping problems, e.g. amylobarbitone
• SSRIs such as fluoxetine or sertraline (for depression). Taking your medicine with these products may cause the following serious side effects: sweating, extreme agitation, confusion, muscle stiffness
• medicines for high blood pressure (e.g. guanethidine, reserpine, methyldopa)
• medicines to treat diabetes (e.g. insulin, metformin)
• antihistamines used to treat allergies, e.g. cetirizine.

Consult your doctor before you take Tranylcypromine Tablets if you are taking or might be taking any of these.

You should NOT take alcohol (especially red wine) whilst you are taking Tranylcypromine Tablets. This includes non-alcoholic beer or lager.

Tranylcypromine Tablets stops the breakdown of a substance called tyramine which is found in large amounts of certain foods. If this substance is not broken down, it can cause very high blood pressure. So, whilst you are taking Tranylcypromine Tablets, you should avoid the following foods:

• matured cheeses (e.g. cheddar or processed cheese made from mature cheese)
• yeast extracts (e.g. Bovril or Marmite)
• meat, fish or poultry which is not fresh or has been pickled
• broad bean pods
• banana skins.

If you are pregnant or breast-feeding, think you may be pregnant or planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Tranylcypromine Tablets should NOT be used during pregnancy or breast feeding unless your doctor thinks it is essential. This medicine may pass into breast milk.

Your doctor will decide whether you should ablactate (gradually reduce) or stop therapy with Tranylcypromine Tablets. Effects of Tranylcypromine Tablets on fertility are unknown.

Tranylcypromine Tablets may make you feel drowsy or dizzy or affect your concentration.

You should not drive or use machines when you first start to take this medicine until you are certain that you are not getting these side effects. If in any doubt, speak to your doctor before you drive or use machines.

If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.

Tranylcypromine Tablets is not recommended for children under 18 years old (see section 2 ‘Children and adolescents’).

If you think that you, or any other person, have taken too many tablets, contact your doctor or hospital casualty department immediately. Take any remaining tablets and this leaflet with you so that the medical staff know exactly what you have taken.

If you miss a dose, wait until your next dose. Do not take a double dose to make up for a forgotten tablet.

You can then carry on as before. Do not take more than one dose at a time.

Continue to take Tranylcypromine Tablets even if you no longer feel ill. DO NOT STOP taking this medicine without talking with your doctor first, especially if you have taken large doses for a long time.

When the time comes to stop your doctor will probably decrease your dose gradually as stopping the tablets suddenly may cause ill-effects such as nausea (feeling sick), vomiting (being sick), sweating and difficulty in sleeping.

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

By reporting side effects you can help provide more information on the safety of this medicine.

Tranylcypromine Tablets are light red coloured, bi-convex, film coated tablets.

They are packed in PVC-PVDC/Aluminium blisters in a Carton containing 28 (7 tablets/blister x 4) and 50 (10 tablets/blister x 5) tablets. Not all pack sizes may be marketed.