Liothyronine Sodium 20 micrograms Powder for Solution for Injection

Keep this leaflet. You may need to read it again.

If you have any further questions, ask your doctor, pharmacist or nurse.

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. See section 4

1. What Liothyronine Sodium injection is and what it is used for
2. What you need to know before you are given Liothyronine Sodium injection
3. How Liothyronine Sodium injection is given to you
4. Possible side effects
5. How to store Liothyronine Sodium injection
6. Contents of the pack and other information

• if you are allergic to liothyronine sodium or any of the other ingredients of this medicine (listed in section 6)
• if you have a disease involving the heart or blood vessels
• if you have pain in the chest (angina pectoris)
• if you have an overactive thyroid gland with raised levels of thyroid hormones (thyrotoxicosis).

Please tell your doctor before you are given this injection if any of the above applies to you.

Talk to your doctor or pharmacist before you are given Liothyronine Sodium injection if you:

• suffer from diabetes. The dosage of your diabetic treatment may need to be altered
• are suffering from a condition called myxoedema (which can happen when you have a problem with your thyroid gland) which makes your skin look swollen and dry
• have heart failure (e.g. suggested by symptoms like swelling of the ankles, breathlessness etc.) or have high blood pressure
• are an elderly patient with history of hypothyroidism (low levels of thyroid hormones)
• suffer from disorders of the adrenal gland.

Tell your doctor or pharmacist if you are using, have recently used or might use any other medicines.

The effects of these medicines may change, especially if you are taking:

• medicines called cardiac glycosides (e.g. digoxin) used to treat heart conditions such as heart failure
• insulin and other treatments for diabetes
• anticonvulsants (e.g. phenytoin, carbamazepine, primidone) used to prevent fits
• anticoagulants (e.g. warfarin, phenindione) used to thin the blood and treat blood clots
• tricyclic antidepressants (e.g. sertraline) used to treat depression
• barbiturates (e.g. amobarbital) taken to induce sleep
• Antihypertensives (propranolol)
• Adrenaline (used to increase heart rate)
• Amiodarone (medication used for irregular heart beat)
• Rifampicin (treatment of tuberculosis).

If you are pregnant or breastfeeding, think you may be pregnant or are planning to have baby, ask your doctor or pharmacist for advice before taking this medicine. The decision on whether it is in your best interests to have Liothyronine Sodium injection during pregnancy or breast feeding will be made by your doctor. Ask your doctor or pharmacist for advice before taking any medicines.

Liothyronine Sodium injection should not interfere with your ability to drive or use machinery.

This medicine also contains Dextran 110 a sugar. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

This medicinal product contains less than 1mmol sodium (23mg) per dose, that is to say essentially ‘sodium-free’.

As the injection will be administered under the supervision of a doctor or nurse, it is unlikely that you will be given more than is necessary. However, if you have any concerns about the dose of your medicine discuss them with your doctor.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Rare (may affect up to 1 in 1, 000 people)

• Benign intracranial hypertension in children (neurological disorder characterized by headache, nausea, vomiting)

Not known (frequency cannot be estimated from the available data):

• Intolerance to heat and Transient hair loss in children (when thyroid hormones used for maintenance)
• Craniostenosis (Developmental abnormality of the skull bone in children)
• Premature closure of epiphysis in children (Bone deformities)

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

By reporting side effects, you can help provide more information on the safety of this medicine.

This medicine is packed as a freeze-dried white plug in a neutral glass vial for reconstitution with 1 or 2 ml of water for injection.

It is available as 5 vials in a carton pack.