Avoid use for more than 1 week as this may result in sensitivity to chloramphenicol or the emergence of resistant organisms. Where chloramphenicol ear drops are used on a long term or intermittent basis, it may be advisable to perform a routine blood profile before therapy and at appropriate intervals thereafter to detect any haemopoietic abnormalities.
Bone marrow hypoplasia, including aplastic anaemia and death, has been reported following topical use of chloramphenicol. Whilst the hazard is a rare one, it should be borne in mind when assessing the benefits expected from the use of the compound.
In severe infections topical use of chloramphenicol should be supplemented with appropriate systemic treatment.
Prolonged use should be avoided as it may increase the likelihood of sensitisation and the emergence of resistant organisms.
If any new infection appears during the treatment, the antibiotic should be discontinued and appropriate measures taken. Chloramphenicol should be reserved for use only in infections for which it is specifically indicated.
Excipient Warnings
This medicine contains 0.95g of propylene glycol in 1ml which is equivalent to 95% w/v.