Patient Leaflet Updated 08-Feb-2022 | SANOFI
Clexane Multidose Vial
CLEXANE® Multidose Vial 30,000 IU(300 mg)/3 mL solution for injection
enoxaparin sodium
1. What Clexane Multidose Vial is and what it is used for
2. What you need to know before you use Clexane Multidose Vial
3. How to use Clexane Multidose Vial
4. Possible side effects
5. How to store Clexane Multidose Vial
6. Contents of the pack and other information
Clexane Multidose Vial contains the active substance called enoxaparin sodium. This belongs to a group of medicines called ‘low molecular weight heparin’ or LMWH.
Clexane Multidose Vial works in two ways:
1) Stopping existing blood clots from getting any bigger. This helps your body to break them down and stops them from causing you harm.
2) Stopping new blood clots from forming in your blood.
Clexane Multidose Vial can be used to:
This medicine contains 15 mg benzyl alcohol per 1 mL. Benzyl alcohol may cause allergic reactions.
Do not use Clexane Multidose Vial if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before using Clexane Multidose Vial.
Clexane Multidose Vial should not be interchanged with other ‘low molecular weight heparins’ such as nadroparin, tinzaparin or dalteparin. This is because they are not exactly the same and do not have the same activity and instructions for use.
Talk to your doctor or pharmacist before using Clexane Multidose Vial if:
If any of the above apply to you (or you are not sure), talk to your doctor or pharmacist before using Clexane Multidose Vial.
Ask your doctor or pharmacist for advice if you have a liver or kidney disease. This is because large amounts of benzyl alcohol can build-up in your body and may cause side effects (called “metabolic acidosis”).
For patients receiving doses higher than 210 mg/day, this medicine contains more than 24 mg sodium (main component of cooking/table salt) in each dose.
This is equivalent to 1.2% of the recommended maximum daily intake of sodium for an adult.
You may have a blood test before you start using this medicine and at intervals while you are using it; this is to check the level of the clotting cells (platelets) and potassium in your blood.
The safety and efficacy of Clexane Multidose Vial has not been evaluated in children or adolescents.
Tell your doctor or pharmacist if you are taking or might take any other medicines.
If you are going to have a spinal or lumbar puncture, or an operation where an epidural or spinal anaesthetic is used, tell your doctor that you are using Clexane Multidose Vial.
If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
If you are pregnant and have a mechanical heart valve, you may be at an increased risk of developing blood clots. Your doctor should discuss this with you.
If you are breast-feeding or plan to breast-feed, you should ask your doctor for advice before taking this medicine.
Ask your doctor or pharmacist for advice if you are pregnant or breast-feeding. This is because large amounts of benzyl alcohol can build-up in your body and may cause side effects (called “metabolic acidosis”).
Clexane Multidose Vial does not affect the ability to drive and operate machinery.
It is advised that the trade name and batch number of the product you are using are recorded by your healthcare professional.
Always use this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
1) Treating blood clots that are in your blood
2) Stopping blood clots from forming in your blood during operations or periods of limited mobility due to an illness
3) Stopping blood clots when you have unstable angina or after you have had a heart attack
NSTEMI (Non-ST segment Elevation Myocardial Infarction) type of heart attack:
STEMI (ST segment Elevation Myocardial Infarction) type of heart attack if you are under 75 years old:
STEMI type of heart attack if you are 75 years old or older:
For patients that have an operation called percutaneous coronary intervention (PCI):
4) Stopping blood clots from forming in the tubes of your dialysis machine
If you are able to give Clexane Multidose Vial to yourself, your doctor or nurse will show you how to do this. Do not try to inject yourself if you have not been trained how to do so. If you are not sure what to do, talk to your doctor or nurse immediately. Performing the injection properly under the skin (called “subcutaneous injection”) will help reduce pain and bruising at the injection site.
Preparing the injection site
1) Choose an area on the right or left side of your stomach. This should be at least 5 centimetres away from your belly button and out towards your sides.
2) Wash your hands. Cleanse (do not rub) the area that you will inject with an alcohol swab or soap and water.
3) Sit or lie in a comfortable position so you are relaxed. Make sure you can see the place you are going to inject. A lounge chair, recliner, or bed propped up with pillows is ideal.
Injecting
1) Withdraw the correct dose from the vial with an appropriate syringe. A drop may appear at the tip of the needle. If this occurs, remove the drop before injecting by tapping on the syringe with the needle pointing down. You are now ready to inject.
2) Hold the syringe in the hand you write with (like a pencil). With your other hand, gently pinch the cleaned area of your stomach between your forefinger and thumb to make a fold in the skin.
3) Hold the syringe so that the needle is pointing straight down (vertically at a 90° angle). Insert the full length of the needle into the skin fold.
4) Press down on the plunger with your thumb. This will send the medication into the fatty tissue of the stomach. Complete the injection using all of the medicine in the syringe.
5) Remove the needle from the injection site by pulling it straight out. Orient the needle away from you and others. You can now let go of the skin fold.
When you have finished
1) To avoid bruising, do not rub the injection site after you have injected yourself.
2) Drop the used syringe into a sharps container. Close the container lid tightly and place the container out of reach of children. When the container is full, dispose of it as your doctor or pharmacist has instructed.
Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
If you think that you have used too much or too little Clexane Multidose Vial, tell your doctor or pharmacist or nurse immediately, even if you have no signs of a problem. If a child accidentally injects or swallows Clexane Multidose Vial, take them to a hospital causualty department straight away.
If you forget to give yourself a dose, have it as soon as you remember. Do not give yourself a double dose on the same day to make up for a forgotten dose.
Keeping a diary will help to make sure you do not miss a dose.
It is important for you to keep having Clexane Multidose Vial injections until your doctor decides to stop them. If you stop, you could get a blood clot which can be very dangerous.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist or nurse.
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Stop using Clexane Multidose Vial and talk to a doctor or nurse straight away if you get any signs of a severe allergic reaction (such as rash, difficulty breathing or swallowing, swelling of the face, lips, tongue, oral cavity, throat or eyes).
Stop using Clexane Multidose Vial and seek medical attention immediately if you notice any of the following symptoms:
Like other similar medicines to reduce blood clotting, Clexane Multidose Vial may cause bleeding. This may be life-threatening. In some cases the bleeding may not be obvious.
Your doctor may decide to keep you under closer observation or change your medicine.
Your doctor may request you perform a blood test to check your platelet count.
Very common (may affect more than 1 in 10 people):
Common (may affect up to 1 in 10 people):
Uncommon (may affect up to 1 in 100 people):
Rare (may affect up to 1 in 1,000 people):
If you get any side effects, talk to your doctor or pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.
Do not store above 25°C. Use within 28 days after opening.
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the label. The expiry date refers to the last day of that month.
Do not use this medicine if you notice a breach in the vial, particulate matters in the solution, or an abnormal colour of the solution (see “What Clexane Multidose Vial looks like and contents of the pack”).
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required.
These measures will help protect the environment.
Clexane multi-dose vial contains a clear, colourless to yellowish solution for injection in a glass vial.
It is supplied in packs of 1, 5, and 10 vials.
Not all pack sizes may be marketed.
This leaflet was last revised in December 2021
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