Patient Leaflet Updated 17-Apr-2023 | Norgine Limited
Isoket 1 mg/ml concentrate for solution for injection or infusion
Isoket® 1 mg/ml Concentrate for solution for injection or infusion
Isosorbide dinitrate
10ml ampoule
1. What Isoket is and what it is used for
2. What you need to know before you use Isoket
3. How to use Isoket
4. Possible side effects
5. How to store Isoket
6. Contents of the pack and other information
Isoket belongs to a group of medicines called organic nitrates. Organic nitrates work by widening the blood vessels in your heart to allow an increased amount of blood to flow to areas which need it. Isoket is used to treat heart failure (heart problems that can cause shortness of breath or ankle swelling) and angina pectoris.
Angina usually feels like a tight pain in the chest, neck or arm area.
It is also used sometimes during surgical procedures on the heart.
Talk to your doctor or nurse before using Isoket if:
Tell your doctor or nurse if you are taking, have recently taken or might take any other medicines, including:
Do not drink alcohol. It could increase the effect of Isoket and lower your blood pressure too much. If this happens, you may feel dizzy or faint.
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or nurse for advice before using this medicine.
Isoket may give you a headache, or make you feel dizzy or tired. If this happens to you, do not drive or operate machinery.
Isoket 1 mg/ml contains 3.54 mg/ml of sodium and may not be suitable for people on a controlled sodium diet. Tell your doctor or nurse before taking Isoket if this applies to you.
Important: Your doctor will choose the dose that is right for you. If you have any questions ask your doctor.
Isoket is a concentrate for intravenous infusion (injected into a vein) and intracoronary injection (injected directly into the artery serving the heart).
Isoket is a concentrate and must be diluted before use. Your doctor or nurse will dilute Isoket with either saline (salt water) or glucose solution before it is given to you.
As this medicine is used in hospital, your heart beat (pulse) and blood pressure will be carefully monitored whilst you are being given Isoket. This is to make sure that your medicine is working properly and that the dose you are taking is right for you.
This medicine is not suitable for children.
As this medicine will be given to you by a doctor or nurse, it is unlikely that you will be given too much or too little.
An overdose of Isoket may cause your blood pressure to be too low resulting in paleness, sweating, weak pulse, fast heartbeat, light-headedness on standing, headache, weakness, dizziness, feeling sick, being sick and diarrhoea. If you have any concerns about this tell your doctor or nurse.
If you have any further questions on the use of this medicine, ask your doctor or nurse.
Like all medicines this medicine can cause side effects, although not everybody gets them.
Very common (may affect more than 1 in 10 people)
Common (may affect up to 1 in 10 people)
Uncommon (may affect up to 1 in 100 people)
Very rare (may affect up to 1 in 10,000 people)
Not known (frequency cannot be estimated from the available data)
red or scaly skin (exfoliate dermatitis)
If you get any side effects, talk to your doctor or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via:
United Kingdom
or search for MHRA Yellow Card in the Google Play or Apple App Store
Ireland
By reporting side effects you can help provide more information on the safety of this medicine.
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the carton. The expiry date refers to the last day of that month.
This medicine does not require any special storage conditions when it is unopened.
Once opened the product should be used immediately.
Do not throw away any medicines via wastewater or household waste. Ask your nurse how to throw away medicines you no longer use. These measures will help protect the environment.
Isoket is a concentrate for solution for infusion and injection. It is a clear solution.
In Ireland
Isoket 1 mg/ml comes in 10 ml glass ampoules.
Each ampoule contains 10 mg of isosorbide dinitrate in 10 ml of solution.
In the UK
Isoket 1 mg/ml comes in 10 ml glass ampoules.
Each ampoule contains 10 mg of isosorbide dinitrate in 10 ml of solution.
Ireland
United Kingdom
This leaflet was last revised in January 2023
If this leaflet is difficult to see or read or you would like it in a different format, please contact:
Ireland:
United Kingdom:
Isoket 1 mg/ml
concentrate for solution for injection of infusion
Isosorbide dinitrate
10 ml ampoule
Norgine House, Widewater Place, Moorhall Road, Harefield, Middlesex, UB9 6NS
+44 (0) 1895 826 606