This guide is for healthcare professionals who will prescribe or dispense ZILBRYSQ (zilucoplan). It describes: • The potential increased risk of meningococcal infections with zilucoplan • How you can mitigate this risk by ensuring patients receive recommended meningococcal vaccinations and, if needed, antibiotic therapy • Important information for starting a patient on zilucoplan • How to counsel patients with the Patient/Carer Guide and Patient Alert Card