This guide informs healthcare professionals about the four identified risks that may occur following Spravato treatment: transient dissociative states and perception disorders (dissociation), disturbances in consciousness (sedation), increased blood pressure and drug abuse. This guide describes the risks and explains how to minimise and manage them.

If you are being treated with Spravato, it is important that you understand the possible risks of taking this medicine. This guide will explain these risks and give you information about how you and your healthcare professional can reduce these risks. This guide does not replace the patient information leaflet that comes with your medicine and you should ensure you have read this prior to taking Spravato.

The treating healthcare professional should use their clinical judgement and this checklist to decide whether the patient is ready to leave after Spravato administration.