• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor, pharmacist or nurse.
• This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
• If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. See section 4.

1. What Trientine is and what it is used for
2. What you need to know before you take Trientine
3. How to take Trientine
4. Possible side effects
5. How to store Trientine
6. Contents of the pack and other information

• if you are allergic to Trientine or any of the other ingredients of this medicine (listed in section 6).

Talk to your doctor, pharmacist or nurse before taking Trientine.

If you were already taking another trientine medicine, your doctor may modify your daily dose when switching to treatment with Trientine.

Your doctor will regularly check your blood and urine to ensure that you receive the right dose of Trientine to properly control your symptoms and copper levels. Regular monitoring is especially important at the start of your treatment, when your dose is changed, in children and pregnant women. Your doctor may need to adjust your dose of Trientine.

This medicine may also reduce the level of iron in your blood and your doctor may prescribe iron supplements (see section “Other medicines and Trientine” below).

If you have kidney or liver problems, your doctor will regularly check that the treatment dose is appropriate and does not affect the functioning of your kidney or liver.

The combination of trientine with zinc, calcium or magnesium antacids is not recommended.

Nervous system problems can occur (shaking, lack of co-ordination, slurred speech, muscle stiffness and worsening of muscle spasms), especially if you are just starting treatment with Trientine. If you notice any of these symptoms whilst taking Trientine, tell your doctor immediately.

Lupus-like reactions (symptoms may include persistent rash, fever, joint pain, and tiredness) have been reported in some patients switched to trientine medicine after penicillamine medicine. However it was not possible to determine if the reaction was due to trientine or to previous penicillamine treatment.

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.

If you are taking iron supplements or indigestion remedies (medicines that reduce discomfort after eating), leave at least two hours before or after taking Trientine because Trientine may not be as effective.

It is recommended that Trientine is taken at least one hour apart from any other medicinal product.

Swallow the capsules with water on an empty stomach, at least one hour before or two hours after meals and at least one hour apart from any other medicines, food, or milk.

If you are pregnant or breast-feeding, think you may be pregnant or are planning to become pregnant, ask your doctor for advice before taking this medicine. You and your doctor can fully discuss the potential benefits of treatment whilst considering any possible risks that there may be with continuing treatment. Your doctor will advise you which treatment and which dose is best in your situation. If you become pregnant whilst taking Trientine, talk to your doctor.

If you are pregnant and taking Trientine, you will be monitored throughout pregnancy for any effects on the baby or changes in copper levels in your blood.

It is not known if Trientine can pass into breast milk. It is important to tell your doctor if you are breast-feeding or plan to do so. Your doctor will then help you decide whether to stop breast-feeding or to stop taking Trientine, considering the benefit of breast-feeding to the baby and the benefit of Trientine to the mother. Your doctor will decide which treatment and which dose is best in your situation.

Trientine is not expected to affect your ability to drive or operate machinery.

This medicine contains less than 1 mmol sodium (23 mg) per capsule, that is to say essentially ‘sodium-free’.

If you think you may have taken more Trientine than you should, contact your doctor or pharmacist immediately. If you have taken more medicine than you should, you may feel or be sick (nausea, vomiting) and dizziness.

If you forget to take a dose, take your next dose as per your usual scheduled time. Do not take a double dose to make up for a forgotten dose.

This medicine is intended for long-term use. Do not stop or change your treatment without speaking to your doctor, even if you feel better.

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App store. By reporting side effects, you can help provide more information on the safety of this medicine.

The active substance is 167 mg trientine, equivalent to 250 mg trientine dihydrochloride.

The other ingredients are:

Capsule content: anhydrous colloidal silica, stearic acid

Capsule shell: gelatin, sodium lauryl sulphate, red iron oxide (E172), yellow iron oxide (E172), titanium dioxide (E171)

Printing ink: shellac, propylene glycol, potassium hydroxide, black iron oxide (E172)

Brown opaque hard gelatin Size 1 capsule imprinted with "HP551" in black ink on the capsule body and cap. The capsule length is between 18.9 mm and 19.7 mm.

White opaque HDPE bottle with a PP child resistant closure: Pack size: 100 capsules

Alu-Alu blister packs: Pack size: 30, 72, 96, 100, 240 and 300 capsules

Not all pack sizes may be marketed.