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The text only version may be available in large print, Braille or audio CD. For further information call emc accessibility on 0800 198 5000. The product code(s) for this leaflet is: PL 00156/0036.
Morphine 10mg/5ml Oral Solution
Morphine 10mg/5ml Oral Solution
Morphine Sulfate
This medicine contains morphine sulfate which is an opioid, which can cause addiction. You can get withdrawal symptoms if you stop taking it suddenly.
1. What Morphine Oral Solution is and what it is used for
2. What you need to know before you take Morphine Oral Solution
3. How to take Morphine Oral Solution
4. Possible side effects
5. How to store Morphine Oral Solution
6. Contents of the pack and other information
This medicine has been prescribed for you for the relief of severe pain.
It contains Morphine Sulfate which belongs to a class of medicines called opioids, which are ‘pain relievers’. This medicine has been prescribed to you and should not be given to anyone else.
Opioids can cause addiction and you may get withdrawal symptoms if you stop taking it suddenly. Your prescriber should have explained how long you will be taking it for and when it is appropriate to stop, how to do this safely.
Do not take Morphine Oral Solution if:
Do not take this medicine if any of the above applied to you If you are not sure, talk to your doctor or pharmacist.
This medicine contains morphine which is an opioid medicine. Repeated use of opioids can result in the drug being less effective (you become accustomed to it, known as tolerance).
Repeated use of Morphine Oral Solution can also lead to dependence, abuse, and addiction, which may result in life-threatening overdose. The risk of these side effects can increase with a higher dose and longer duration of use.
Dependence or addiction can make you feel that you are no longer in control of how much medicine you need to take or how often you need to take it.
The risk of becoming dependent or addicted varies from person to person. You may have a greater risk of becoming dependent on or addicted to Morphine Oral Solution if:
If you notice any of the following signs whilst taking Morphine Oral Solution, it could be a sign that you have become dependent or addicted:
If you notice any of these signs, speak to your doctor to discuss the best treatment pathway for you, including when it is appropriate to stop and how to stop safely (See section 3, If you stop taking Morphine Oral Solution)
Talk to your doctor or pharmacist before taking Morphine Oral Solution if:
Taking this medicine regularly, particularly for a long time, can lead to addiction. Your prescriber should have explained how long you will be taking it for and when it is appropriate to stop, how to do this safely.
Rarely, increasing the dose of this medicine can make you more sensitive to pain. If this happens, you need to speak to your prescriber about your treatment.
Addiction can cause withdrawal symptoms when you stop taking this medicine. Withdrawal symptoms can include restlessness, difficulty sleeping, irritability, agitation, anxiety, feeling your heartbeat (palpitations), increased blood pressure, feeling or being sick, diarrhoea, loss of appetite, shaking, shivering or sweating. Your prescriber will discuss with you how to gradually reduce your dose before stopping the medicine. It is important that you do not stop taking the medicine suddenly as you will be more likely to experience withdrawal symptoms.
Opioids should only be used by those they are prescribed for. Do not give your medicine to anyone else. Taking higher doses or more frequent doses of opioid, may increase the risk of addiction. Overuse and misuse can lead to overdose and/or death.
Talk to your doctor, pharmacist or nurse if you experience any of the following symptoms while taking Morphine Oral Solution:
If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Morphine Oral solution.
Acute generalized exanthematous pustulosis (AGEP) has been reported in association with Morphine Oral Solution treatment. Symptoms usually occur within the first 10 days of treatment. Tell your doctor if you have ever developed a severe skin rash or skin peeling, blistering and/or mouth sores after taking Morphine Oral Solution or other opioids. Stop using Morphine Oral Solution and seek medical attention immediately, if you notice any of the following symptoms: blistering, widespread scaly skin or pus-filled spots together with fever.
Morphine Oral Solution can cause sleep-related breathing disorders such as sleep apnoea (breathing pauses during sleep) and sleep related hypoxemia (low oxygen level in the blood). The symptoms can include breathing pauses during sleep, night awakening due to shortness of breath, difficulties to maintain sleep or excessive drowsiness during the day. If you or another person observe these symptoms, contact your doctor. A dose reduction may be considered by your doctor.
Contact your doctor if you experience severe upper abdominal pain possibly radiating to the back, nausea, vomiting or fever as this could be symptoms associated with inflammation of the pancreas (pancreatitis) and the biliary tract system.
Tell your doctor if you are taking or have recently taken any other medicines, including those obtained without prescription. This includes medicine that you buy without a prescription and herbal medicines. This is because Morphine Oral Solution can affect the way some other medicines work. Also some other medicines can affect the way Morphine Oral Solution works.
Morphine Oral Solution must not be used with drugs used to treat severe depression, such as phenelzine or moclobemide, or if you are within 2 weeks of discontinuing them.
These drugs are known as Monoamine Oxidase Inhibitors (MAOI’s).
In particular tell your doctor or pharmacist if you are taking any of the following medicines:
However if your doctor does prescribe Morphine Oral solution together with sedative medicines the dose and duration of concomitant treatment should be limited by your doctor.
Please tell your doctor about all sedative medicines you are taking, and follow your doctor’s dose recommendation closely. It could be helpful to inform friends or relatives to be aware of the signs and symptoms stated above.
Contact your doctor when experiencing such symptoms.
You should avoid alcohol whilst taking this medicine.
Pregnancy
Do not take Morphine Oral Solution if you are pregnant or think you might be pregnant unless you have discussed this with your prescriber and the benefits of treatment are considered to outweigh the potential harm to the baby.
If you use Morphine Oral Solution during pregnancy, your baby may become dependent and experience withdrawal symptoms after the birth which may need to be treated.
Do not take Morphine oral Solution while you are breastfeeding as morphine sulfate passes into breast milk and will affect your baby. If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.
Tell your doctor or pharmacist if you are due to have an operation or an anaesthetic or if you have had an operation or an anaesthetic within the last 24 hours.
This medicine can affect your ability to drive and operate machinery as it may make you sleepy or dizzy.
Talk to your doctor or pharmacist if you are not sure whether it is safe for you to drive while taking this medicine.
This effect is even more enhanced, when used in combination with alcohol or CNS depressants (medicines for sleeping disorders and anxiety). Do not drive or operate machinery if you feel drowsy or cannot think clearly.
Do not drink directly from the bottle as this may result in you taking the incorrect dose (too little or too much). Taking too much may result in an overdose with potential for serious consequences including unconsciousness and even death.
Before starting treatment and regularly during treatment, your doctor will discuss with you what you may expect from using Morphine Oral Solution, when and how long you need to take it, when to contact your doctor, and when you need to stop it (see also, If you stop using Morphine Oral Solution, in this section).
Your prescriber should have discussed with you, how long the course of Morphine Oral Solution will last.
They will arrange a plan for stopping treatment. This will outline how to gradually reduce the dose and stop taking the medicine. Always follow the instructions of your doctor and pharmacist. If you are changing from other types of morphine medication your doctor may have to change your dose.
Adults: Recommended dose is one or two 5ml spoonfuls (10-20mg) every 4 hours
Elderly and infirm patients: A reduced dose is recommended
Children: 13 to 18 years: Recommended dose is half or two 5ml spoonfuls (5-20mg) every 4 hours
6 to 12 years: Recommended dose of is half or one 5ml spoonfuls (5-10mg) every 4 hours
1 to 5 years: recommended dose is half a 5ml spoonful (5mg) every 4 hours
Under 1 year: not recommended
If you take more of this medicine than you should, talk to a doctor or go to a hospital straight away. Take the medicine pack with you. This is so the doctor knows what you have taken.Symptoms of an overdose include sudden or unexpected difficulty in breathing, pin-point pupils (the black circle in the centre of your eyes (pupil) getting smaller) or a drop in blood pressure. In the case of infants and children they may suffer fits (convulsions).
People who have taken an overdose may get pneumonia from inhaling vomit or foreign matter, symptoms may include breathlessness, cough and fever.
People who have taken an overdose may also have breathing difficulties leading to unconsciousness or even death.
In more severe cases, very high doses could cause your blood circulation to slow down and cause unconsciousness for a long time, or even death.
Do not suddenly stop taking this medicine. If you want to stop taking this medicine, discuss this with your prescriber first. They will tell you how to do this, usually by reducing the dose gradually so that any unpleasant withdrawal effects are kept to a minimum. Withdrawal symptoms such as restlessness, difficulty sleeping, irritability, agitation, anxiety, feeling your heartbeat (palpitations), increased blood pressure, feeling or being sick, diarrhoea, shaking, shivering or sweating may occur if you suddenly stop taking this medicine.
Like all medicines, Morphine Oral Solution can cause side effects but not everyone gets them.
Allergic reaction
If you have a severe allergic reaction, stop taking this medicine and see and doctor straight away. Signs may include swelling of the mouth and face, difficult breathing, dizziness and skin reactions such as rash and itching.
When you stop taking Morphine Oral Solution, you may experience drug withdrawal symptoms, which include restlessness, difficulty sleeping, irritability, agitation, anxiety, feeling your heartbeat (palpitations), increased blood pressure, feeling or being sick, diarrhoea, shaking, shivering or sweating.
If you notice any of the following signs whilst taking Morphine Oral Solution, it could be a sign that you have become addicted.
If you notice any of these signs, it is important you talk to your prescriber
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
By reporting side effects you can help provide more information on the safety of this medicine.
Keep this medicine out of the sight and reach of children.
Do not use this product after the expiry date which is stated on the carton. The expiry date refers to the last day of that month. Keep container in the outer carton. Use within 90 days of first opening.
Do not store above 25°C. Store in the original container in order to protect from light.
Please return any remaining medicine to your pharmacist 90 days after first opening.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.
Active ingredient: Morphine Sulfate Ph Eur 10mg in each 5ml of solution.
Other ingredients: sugar (sucrose), alcohol, disodium edetate, sodium propyl hydroxybenzoate (E217), sodium methyl hydroxybenzoate (E219), raspberry flavour, purified water and may include hydrochloric acid.
Each 5ml dose of this solution contains 0.4ml of alcohol and 2.25g of sugar.
The clear, colourless or almost colourless solution is supplied in amber glass bottles containing 100ml, 250ml, 300ml or 500ml.
Not all pack sizes may be marketed.
Product Licence No.: PL 00156/0036
This leaflet was last revised in: December 2023
D06142