Panadol NightPain Film-coated Tablets

This medicine is available without prescription, but you still need to use Panadol Night carefully to get the best results from them.

• Keep this leaflet you may need to read it again.
• If you have any questions, or if there is anything you do not understand, ask your pharmacist.

1. What Panadol Night does
2. Check before you take Panadol Night
3. How to take Panadol Night
4. Possible side effects
5. How to store Panadol Night
6. Further information

• if you have ever had an allergic reaction to paracetamol, diphenhydramine hydrochloride or to any of the other ingredients (listed in Section 6)
• if you have porphyria (too much of the pigment called porphyrin which may discolour the urine)
• if you have taken another medicine containing paracetamol in the last 4 hours.

Contains paracetamol.

Do not take with any other antihistamine-containing products, including those used on your skin or in cough and cold medicines.

• if you have liver or kidney problems, including alcoholic liver disease, are underweight or malnourished or regularly drink alcohol. You may need to avoid using this product altogether or limit the amount of paracetamol that you take.
• if you have epilepsy, or seizure disorders
• if you have an obstruction in your stomach or gut (for example, because of an ulcer)
• if you experience difficulty passing urine
• if you have narrow-angle glaucoma (raised pressure in the eye)
• if you have an enlarged prostate
• if you have myasthenia gravis
• if you have asthma, bronchitis or Chronic Obstructive Pulmonary Disease (COPD)
• if you have been told by your doctor that you have an intolerance to some sugars.

Contact a doctor immediately if you get a combination of these symptoms.

During treatment with Panadol Night , tell your doctor straight away:

If you have severe infection or severe illnesses, including severe renal impairment or sepsis (when bacteria and their toxins circulate in the blood leading to organ damage), or you suffer from malnutrition, chronic alcoholism or if you are also taking flucloxacillin (an antibiotic). A serious condition called metabolic acidosis (a blood and fluid abnormality) has been reported in patients in these situations when paracetamol is used at regular doses for a prolonged period or when paracetamol is taken together with flucloxacillin. Symptoms of metabolic acidosis may include: serious breathing difficulties with deep rapid breathing, drowsiness, feeling sick (nausea), being sick (vomiting) and loss of appetite.

• Do not drive or operate machinery. Panadol Night is intended to produce sleepiness or drowsiness soon after the dose is taken.
• Do not drink alcohol while using Panadol Night

Talk to your doctor or pharmacist before taking these tablets if you are taking any prescribed medicines; particularly monoamine oxidase inhibitors (MAOIs) in the last 2 weeks or tricyclic antidepressants (prescribed for depression); atropine; beta blockers (to treat heart problems); metoclopramide or domperidone (for nausea or vomiting); metoprolol or venlafaxine; colestyramine (to lower blood cholesterol); medicines for stomach cramps (e.g. dicycloverine) or travel sickness (e.g. hyoscine); medicines to treat anxiety or to help you sleep; medicines that make you drowsy or give you a dry mouth; blood thinning drugs (anticoagulants e.g. warfarin) or painkillers (e.g. codeine); flucloxacillin (antibiotic), due to a serious risk of blood and fluid abnormality (called metabolic acidosis) that must have urgent treatment (see section 2).

Do not take Panadol Night if you are pregnant or breast feeding.

Talk to a doctor at once if you take too much of this medicine even if you feel well. This is because too much paracetamol can cause delayed, serious liver damage.

If your bedtime pain carries on for more than one week, or if your headache becomes persistent, see your doctor.

• Drowsiness, sedation, unsteadiness, dizziness, tiredness, blurred vision, or difficulty concentrating
• Dry mouth
• Feeling restless or excitable, confusion
• Tingling sensation in the skin
• Muscle twitching
• A serious condition that can make blood more acidic (called metabolic acidosis), in patients with severe illness using paracetamol (see section 2).

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects, you can help provide more information on the safety of this medicine.