• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or your pharmacist.
• This medicine has been prescribed only for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.
• If any of these side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

1. What Amiloride Tablets are and what they are used for
2. Before you take Amiloride Tablets
3. How to take Amiloride Tablets
4. Possible side effects
5. How to store Amiloride Tablets
6. Further information

• You are allergic (hypersensitive) to amiloride or any other ingredients in this medicine (listed in Section 6 below). Signs of an allergic reaction include: a rash, itching or shortness of breath
• You have kidney problems
• Your doctor has told you that you have high potassium levels or you are taking other potassium conserving drugs or potassium supplements
• The person taking the medicine is a child under 18 years old.

Do not take this medicine if any of the above apply to you. If you are not sure, talk to your doctor before taking Amiloride Tablets.

Before you take Amiloride Tablets tell your doctor if:

• You are elderly or seriously ill
• You have diabetes
• You have liver problems
• Your doctor has told you that you have too much acid in your blood. This can be caused by diabetes or heart or lung disease.

If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Amiloride Tablets.

Tell your doctor or nurse you are taking Amiloride Tablets if you are going to have a glucose tolerance test. This is because this medicine can affect the results. You will need to stop taking this medicine three days before your test.

Please tell your doctor of pharmacist if you are taking or have recently taken any other medicines.

This includes medicines you buy without a prescription, including herbal medicines. This is because Amiloride Tablets can affect the way some other medicines work. Also, some medicines can affect the way Amiloride Tablets work.

In particular, tell your doctor if you are taking any of the following:

• Lithium - used for depression
• Medicines used to treat high blood pressure including ACE inhibitors, angiotensin-II antagonists, alpha-blockers, beta-blockers, calcium channel blockers and hydralazine
• Nitrates - used for angina
• Quinidine - used to treat heart rhythm disorders
• Medicines or supplements containing potassium (including table salt substitutes)
• Trilostane – used to treat kidney and skin cancer (melanoma)
• Ciclosporin or tacrolimus – used after transplants to stop the rejection of organs
• General anaesthetics, used to stop pain during surgery
• Non-steroidal anti-inflammatory (NSAID) medicines such as indometacin, diclofenac and ibuprofen. Your doctor may want to carry out tests on your kidneys and the level of potassium in your blood, especially if you are an older person
• Chlorpropramide - used to treat diabetes
• Carbamazepine - used for epilepsy
• Levodopa – used to treat Parkinson’s disease
• Medicines used to treat depression including tricyclic antidepressants (such as amitriptyline) and monoamine oxidase inhibitors (MAOIs – such as phenelzine)
• Phenothiazines – used to treat mental illness
• Medicines used to treat inflammation (such as cortisone and hydrocortisone)
• Tizanidine or baclofen – used to relax muscles
• Carbenoxolone – used to treat stomach ulcers
• Some oral contraceptives (the pill) or oestrogen (female sex hormone) preparations
• Alprostadil – used to treat male impotence and for heart defects in infants.

This medicine does not cause loss of potassium from your body as other water tablets do.

Therefore, it is not necessary for you to get extra potassium in your diet or take supplements. Too much potassium could even be harmful.

If you feel dizzy while taking the tablets drinking alcohol can make this problem worse.

Talk to your doctor before taking this medicine if you are pregnant, planning to become pregnant or are breast-feeding.

If you feel dizzy while taking Amiloride Tablets do not drive or operate dangerous machinery.

This medicine contains:

• Lactose monohydrate. If your doctor has told you that you cannot tolerate some sugars, see your doctor before taking this medicine.

• Take this medicine by mouth
• If you are taking a single dose, take it in the morning
• If you are taking more than one dose, take the last dose before 6pm, unless your doctor tells you otherwise
• Plan your doses so that they do not affect your personal activities and sleep
• Your doctor will check your progress regularly to make sure the medicine is working properly.

The usual doses for adults are:

• 10mg each day
• This may be increased to 20mg each day.

• 5mg or 10mg each day.

• 5mg each day.

This medicine is not usually given to children under the age of 18.

Your doctor will decide how many Amiloride Tablets to give you.

Talk to a doctor or go to a hospital straight way.

Take the medicine pack with you so the doctor knows what you have taken.

Do not take a double dose (two doses at the same time) to make up for a forgotten dose. Take your next dose as soon as you remember, then go on as before. However, if it is nearly time for the next dose, skip the missed dose. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

An allergic reaction may include:

• Any kind of skin rash, flaking skin, boils or sore lips and mouth
• Sudden wheezing, fluttering or tightness of the chest or collapse.

• Chest pain including angina pain
• Unusual heart beats
• Yellowing of the skin and the whites of the eyes (jaundice)
• Feeling dizzy, particularly when standing up
• Disease of the brain (encephalopathy)
• Difficulty breathing
• Problems with your sight
• Changes in the results of blood tests. These include changes in the way your liver is working or changes in red or white blood cell levels. They also include changes in sodium or potassium levels which can cause dry mouth, thirst, headaches, muscle cramps and weakness.

• Feeling sick or being sick
• Diarrhoea or constipation
• Stomach pain
• Skin rash, itching
• Hair loss
• Pins and needles
• Feeling confused
• Mood or personality changes
• Feeling sleepy
• Coughing
• Changes in your sexual drive and function.

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the yellow card scheme at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

By reporting side effects you can help provide more information on the safety of this medicine.

• The active ingredient is amiloride hydrochloride
• The other ingredients are lactose monohydrate, starch, povidone, sodium starch glycollate, magnesium stearate, dispersed quinoline yellow lake E104 and isopropanol.

Amiloride Tablets are yellow, round tablets marked AML5 with a breakline on one side and CP on the reverse.

They are available in blister packs of 28 tablets.

Other formats:

To listen to or request a copy of this leaflet in Braille, large print or audio please call, free of charge: 0800 198 5000 (UK only)

Please be ready to give the following information:

Product name Reference number

Amiloride 5mg Tablets PL 29831/0006

This service is provided by the Royal National Institute of Blind People.

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