This medicine is a traditional herbal medicinal product available without prescription to treat minor conditions. However, you still need to take it carefully to get the best results from it.

• Keep this leaflet, you may need to read it again
• Ask your pharmacist if you need more information or advice
• You must contact a pharmacist or doctor if your symptoms worsen or do not improve after 6 weeks

• If you are under 18 years
• If you are allergic to any of the ingredients (see “What is in this medicine”)
• If you have been diagnosed with depression or you think you may be depressed (see “Other important information”)
• If your skin is very sensitive to sunlight
• If you are having light treatment
• If you are about to have an operation (see “Other important information”)
• If you have an intolerance to some sugars, unless your doctor tells you to (this medicine contains lactose)
• If you are pregnant or breastfeeding

Symptoms of depression include feelings of helplessness and hopelessness, loss of interest in daily activities, changes in appetite or weight, changes in sleeping patterns or habits, loss of energy and difficulty in concentrating. If your doctor has told you that you have depression, do not take this medicine. It does not relieve the symptoms of depression. If you think you have depression talk to your doctor before taking this medicine.

If you need to go into hospital for an operation, tell the doctor that you are taking this medicine. Stop taking this medicine at least 10 days before your operation so that it does not affect the anaesthetic or pain medicines that you need.

Avoid excessive sunbathing or the use of sunbeds/solariums while you are taking this medicine.

Driving and using machines: This medicine may cause you to feel dizzy or sleepy. If you are affected do not drive or use machines.

You should not take this medicine if you are taking certain medicines (see below).

If you are not sure whether your medicine is on this list, or you are unsure about interactions with any other medicines, talk to your pharmacist. This includes medicines prescribed by your doctor or medicine you have bought for yourself.

Do not take this medicine if you are taking any of the following medicines:

• All hormonal contraceptives – the birth control ‘Pill’, emergency contraception (also known as “the morning after pill”), hormonal implant, creams, patches, intra-uterine devices with hormones
• All medicines for depression/anxiety – amitriptyline, clomipramine, moclobemide, citalopram, fluoxetine, paroxetine, sertraline, duloxetine, venlafaxine
• All hormonal replacement therapy (HRT) treatments – HRT tablets, patches, gels, vaginal rings
• All medicines for thinning the blood (anticoagulants) – warfarin, acenocoumarol
• All medicines for epilepsy – carbamazepine, phenobarbitone, phenytoin, primidone, sodium valproate
• All immunosuppressant medicines – ciclosporin, tacrolimus
• All medicines for HIV infections – amprenavir, atazanavir, darunavir, fosamprenavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, tipranavir, efavirenz, nevirapine, delaviridine
• Some medicines for cholesterol – simvastatin, atorvastatin
• Some medicines for cancer – irinotecan, dasatinib, erlotinib, imatinib, sorafenib, sunitinib, etoposide, mitotane
• Some medicines for heart disease - digoxin, ivabradine, amiodarone
• Some medicines for migraine - almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
• Some medicines for high blood pressure - amlodipine, nifedipine, felodipine, verapamil
• A medicine for regulating mood – lithium
• A thyroid hormone - thyroxine

St John’s W ort may also affect the following medicines. Therefore do not take this medicines at the same time, unless a doctor has said it is safe to do so:

• Fentanyl, propofol, sevoflurane, midazolam (anaesthetics/pre-operative medicines)
• Tramadol (an analgesic)
• Erythromycin, clarithromycin, telithromycin (antibiotics)
• Itraconazole and voriconazole (antifungals)
• Artemether and lumefantrine (antimalarials)
• Rasagiline (for Parkinson’s disease)
• Aripiprazole (an antipsychotic medicine)
• Buspirone (an anxiolytic)
• Aprepitant (used to treat post-operative vomiting)
• Butobarbital and phenobarbital (barbiturates)
• Methyl phenidate (a central nervous system stimulant)
• Exemestane (a hormone antagonist for breast cancer)
• Eplerenone (a diuretic or water tablet)
• Lansoprazole and omeprazole (proton pump inhibitors for heartburn)
• Theophylline (a bronchodilator for breathing problems)
• Gliclazide (for diabetes)

• Allergic reactions (skin rash, hives, red itchy skin)

• Stomach problems, e.g. indigestion, loss of appetite, feeling sick (nausea), diarrhoea, constipation
• Fatigue, restlessness
• Sunburn-like reactions in skin exposed to strong sunlight or strong ultra-violet (UV) irradiation e.g. solarium, particularly in fair skinned individuals
• Headache, nerve pain or tingling, dizziness, mania (raised excitability), anxiety

If any side effect becomes severe, lasts more than a few days, or you notice any side effect not listed here, please tell your pharmacist or doctor.

If you get any side-effects, talk to your doctor, pharmacist or qualified healthcare practitioner. This includes any possible side effects not listed in the package leaflet. You can also report side-effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or apple App Store. By reporting side-effects you can help provide more information on the safety of this medicine.