• Keep this leaflet. You may need to read it again.
• If you have any further questions about your illness or your medicine, ask your doctor, nurse or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.
• If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor, nurse or pharmacist.

1. What Mivacurium injection is and what it is used for
2. What you need to know before you are given Mivacurium injection
3. How Mivacurium injection is given
4. Possible side effects
5. How to store Mivacurium injection
6. Contents of the pack and other information

• you are allergic to mivacurium, any other muscle relaxant or any of the other ingredients in Mivacurium injection (listed in Section 6)
• you or your family have reacted badly to an anaesthetic before.

Do not have mivacurium if any of the above apply to you. If you are not sure, talk to your doctor, nurse or pharmacist before you have mivacurium.

Talk to your doctor, nurse or pharmacist before having this medicine if:

• you have muscle weakness, tiredness or difficulty in co-ordinating your movements (myasthenia gravis)
• you have a neuromuscular disease, such as a muscle wasting disease, paralysis, motor neurone disease or cerebral palsy
• you have a burn which requires medical treatment
• you have ever had an allergic reaction to any muscle relaxant that was given as part of an operation.

Talk to your doctor before having this medicine, if you have or have ever had any of the following:

• Tetanus
• A severe or long-standing infection such as tuberculosis (TB)
• Any long-standing illness which has left you weak
• Cancer
• Anaemia
• Malnutrition
• An under-active thyroid gland
• Heart disease
• Stomach ulcers
• Burns
• Liver or kidney disease

Tell your doctor if:

• You are pregnant or have been pregnant recently or you have given birth in the last 6 weeks.
• You have been diagnosed as having a genetically determined abnormal cholinesterase.
• You are particularly sensitive to histamine or if you have asthma.

If you are not sure if any of the above apply to you, talk to your doctor, nurse or pharmacist before you are given mivacurium.

Tell your doctor, nurse or pharmacist if you are taking or have recently taken any other medicines. This includes medicines obtained without a prescription, including herbal medicines. This is because these medicines can affect how well mivacurium works or can cause side effects.

In particular tell your doctor, nurse or pharmacist if you are taking any of the following:

• anaesthetics (used to reduce sensation and pain during surgical procedures)
• antibiotics (used to treat infections)
• medicines for uneven heart beats (anti-arrhythmics)
• medicines for high blood pressure
• water tablets (diuretics), such as furosemide (previously known as frusemide)
• medicines for inflammation of the joints, such as chloroquine or d-penicillamine
• steroids
• medicines for mental illness, such as lithium, monoamine oxidase inhibitors (MAOIs) or chlorpromazine (which can also be used for sickness)
• medicines containing magnesium.
• medicines used to treat depression and/or anxiety SSRIs (selective serotonin reuptake inhibitors) including fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, escitalopram

If you are pregnant, or are breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before being given this medicine.

It can be dangerous to drive or operate machinery too soon after having had an operation. Your doctor will tell you how long to wait before you can drive and use machinery.

You will never be expected to give yourself this medicine. It will always be given to you by a person who is qualified to do so.

Mivacurium can be given:

• as a single injection into your vein (intravenous bolus injection)
• as a continuous infusion into your vein. This is where the drug is slowly given to you over a long period of time.

Your doctor will decide the way you are given the drug and the dose you will receive. It will depend on:

• your body weight
• the amount and duration of muscle relaxation required
• your expected response to the medicine.

Children under 2 months old should not have this medicine.

Mivacurium will always be given under carefully controlled conditions. However, if you think that you have been given more than you should tell your doctor or nurse immediately.

If you get any side effects, talk to your doctor, nurse or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme

Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

By reporting side effects you can help provide more information on the safety of this medicine.

• The active substance is mivacurium chloride.
• The other ingredients are hydrochloric acid and Water for Injections.

• Mivacurium solution for injection comes in ampoules containing 5 ml or 10 ml of the product.

Marketing Authorisation holder:

Manufacturer:

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To listen to or request a copy of this leaflet in Braille, large print or audio please call, free of charge:

0800 198 5000 (UK only).

Please be ready to give the following information:

Product name Mivacurium 2mg/ml injection

Reference number PL 39699/0094

This is a service provided by the Royal National Institute of Blind People.